On November 8, 1994, Bishop Edward O'Donnell of St. Louis was appointed fifth Bishop of Lafayette. The St. Louis native had been pastor, administrator and auxiliary bishop in St. Louis. He was installed on December 16, 1994 in ceremonies in St. John Cathedral.
In his eight years as Bishop of Lafayette, Bishop O'Donnell initiated planning and programs in anticipation of the third millennium of Christianity. In a diocese which has one of the highest percentages of Black Catholics in the U.S., he encouraged an increased presence by Black Catholics in diocesan and parish affairs.